Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a joint strike against an hidden munitions depot in Syria employed by the IS group, according to the UK's MoD.
The facility, located using surveillance, was believed to be containing munitions and bombs, the statement said, and was situated in mountains just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to hit a several entry passages down to the site... initial indications indicate the strike was effective," the MoD said.
There was no sign of any harm to civilians in the attack conducted Saturday night and all the aircraft returned safely, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
IS - alternatively referred to as Daesh - enforced militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This action shows British leadership, and resolve to work closely with our partners, to eliminate any re-emergence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have carried out patrols over Syrian airspace to "forestall any efforts to regroup" of IS following its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to all the members of British forces participating in this mission for their skill and their valour," he added. "They were among thousands of British troops stationed over the festive period. This mission, to eliminate terrorist threats who pose a risk to our security, highlights how British military are ready to step up, continuously, ensuring Britain's security within its borders and influential overseas."
During December, the United States armed forces carried out what it termed a "massive strike" targeting IS targets in Syria, after an assault resulted in the deaths of two US troops and a local interpreter in Palmyra.
The UN says Daesh still has roughly 5-7 thousand combatants in Iraq and Syria.
